Overall this text provides a summary of the status of radionuclide imaging of hypoxia the material is clearly prestented well referenced and authoritative the text is concise and should serve as a reference for investigators interested in pursuing work in this field european journal of nuclear medicine 2852001. Pet imaging of hypoxia starting with the 2 nitroimidazole family of compounds in the early 1980s 1521 a great number of pet tracers have been developed for the identification of hypoxia in living tissues and solid tumors table 2the driving force behind this development has been the need for highly specific imaging probes able to overcome the inconsistent correlation between . Get this from a library imaging of hypoxia tracer developments hans jurgen machulla hypoxia ie insufficient availability of oxygen within the tissue is a more serious problem than realized in clinical routine work although a large variety of theoretical and experimental data . Get this from a library imaging of hypoxia tracer developments hans jurgen machulla as the result of a workshop held by the radiopharmacy in tubingen the book collects the data of observations and findings in order to stimulate the on going research ending up in important clinical . Hypoxia is a key player in the angiogenic see page 597switch during tumor development a key regulator of hypoxia induced angiogenesis is the hypoxia inducible factor 1 hif 1 multiple hif 1 target genes have been shown to modulate angiogenesis by promoting the mitogenic and migratory activities of endothelial cells
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