Since approximately half of the elderly population exhibits only negligible brain alterations mr imaging may facilitate the distinction between usual no neurologic dysfunction and successful no brain or vascular changes aging. Topics covered include technical factors in brain imaging pathological basis of age related structural and functional changes neurochemistry and genetics of brain imaging in aging and the use of imaging techniques in diagnosis longitudinal testing drug development and testing and presymptomatic detection. The study of brain aging has been revolutionized through advances in molecular neuroscience cognitive neuroscience and brain imaging the application of new concepts and techniques has permitted investigators to explore the changes in structure function and biochemistry in living humans in order to unravel mechanisms that underlie both age related cognitive decline and preservation of . One primary goal of functional brain imaging is to identify regions of the brain whose activation correlates with psychological events of interest standard brain imaging analysis programs begin by constructing a regression model with the predicted timecourses for these psychological events. Imaging of the aging brain part i normal findings drayer bp1 author information 1barrow neurological institute phoenix az 85013 a thorough knowledge of the normal changes that occur in the brain with age is critical before abnormal findings are analyzed
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